Risk assessment of plaque rupture and future cardiovascular events by multi-spectral photoacoustic imaging



Publications by the CVENT partners


March 2020
Three-dimensional view of out-of-plane artifacts in photoacoustic imaging using a laser-integrated linear-transducer-array probe
Ho Nhu Y. Nguyen, Wiendelt Steenbergen
Photoacoustics | Volume 19 | 100176

June 2019
Reducing artifacts in photoacoustic imaging by using multi-wavelength excitation and transducer displacement
Ho Nhu Y. Nguyen, Wiendelt Steenbergen
Biomedical Optics Express | 10/7 | pages 3124-3138

December 2018
Receive beam steering and clutter reduction for imaging the speed-of-sound inside the carotid artery
Maju Kuriakose, Jan-Willem Muller, Patrick Stähli, Martin Frenz, Michael Jaeger
Photoacoustics | Volume 10 | pages 20-30

October 2018
Reflection artifact identification in photoacoustic imaging using multi-wavelength excitation
Ho Nhu Y. Nguyen, Altaf Hussain, and Wiendelt Steenbergen
Biomedical Optics Express | Volume 9 | Issue 10 | pages 4613-4630

June 2018
Rapid scanning wide-field clutter elimination in epi-optoacoustic imaging using comb LOVIT
Tigran Petrosyan, Maria Theodorou, Jeff Bamber, Martin Frenz, Michael Jaeger
Journal of Imaging | Volume 4 | no 12 | pp 145

May 2018
Recent Development of Technology and Application of Photoacoustic Molecular Imaging Toward Clinical Translation
Jaesok Yu, Ho Nhu Y. Nguyen, Wiendelt Steenbergen, Kang Kim
Journal of Nuclear Medicine | 59/8 | pages 1202-1207

January 2018
Investigation on the Effect of Spatial Compounding on Photoacoustic Images of Carotid Plaques in the In Vivo Available Rotational Range
M. Umit Arabul, H. Maarten Heres, Marcel C. M. Rutten, Marc R. H. M. van Sambeek, Frans N. van de Vosse, Richard G. P. Lopata
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control | 65/3

December 2017
Feasibility of photoacoustic/ultrasound imaging of synovitis in finger joints using a point-of-care system
Pim J. van den Berg, Khalid Daoudi, Hein J. Bernelot Moens, Wiendelt Steenbergen
Photoacoustics | Volume 8

6-9 September 2017
Aberration correction in photoacoustic imaging using paraxial backpropagation
Hans-Martin Schwab, Andreas Ihrig, Dominic Depke, Sven Hermann, Michael Schafers, Georg Schmitz
2017 IEEE International Ultrasonics Symposium | September 2017

1 April 2017
Photoacoustic reflection artifact reduction using photoacoustic-guided focused ultrasound: comparison between plane-wave and element-by-element synthetic backpropagation approach
Mithun Kuniyil Ajith Singh, Michael Jaeger, Martin Frenz, Wiendelt Steenbergen
Biomedical Optics Express | 8/4



CVENT Movie for patients


CVENT Movie for scientists

Online training

Public summaries by the CVENT partners

CVENT modules
CVENT training summaries
The CVENT research and development fields are the signal processing, probe development, system integration and clinical validation. The main effort is dedicated to reach a breakthrough in functional photoacoustic imaging to extract morphological features from the multi-wavelength PA/US data to receive functional information of plaques in the carotid artery.

Find here the full set of public CVENT summaries about the four training modules and selected management and exploitation summaries.

Probe development
The CVENT multi-wavelength photoacoustic/ultrasound (PA/US) probe components are produced by Brigthloop (laser diode driver), SILIOS (beam homogenizer), LUMIBIRD (laser diode source), and ESAOTE (ultrasound probe).
  • Specifications
  • 1st prototype
  • 2nd prototype
  • Final prototype
Signal processing
A main requirement for successful photoacoustic imaging (PAI) of the carotid artery using the CVENT probe is extensive averaging to achieve sufficient Signal Noise Ratio at the depth of the artery.
  • Clutter and noise algorithms.
  • Speed of Sound
  • Tissue characterisation
  • PAI-US elastography.
  • Image aberration correction.
System integration
the strategy of a fully functional ultrasound (US) system with a cardiovascular PAI ad-on module.
  • System architecture
  • Low level programming
  • High performing computing
  • PA/US probe ergonomics
Clinical validation
CVENT is focused on cardiovascular diseases patients to screen, diagnose and monitor carotid plaque vulnerability.
  • Plaque testing setup.
  • First in-vitro results
  • In-vivo pilot study finalised
  • In-vivo and in-vitro study